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Shilpa, T. N.
- Polymeric Novel Vesicular Drug Delivery System:An Updated Overview of Microspheres
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1 S V U College of Pharmaceutical Sciences, S V University, Tirupati, IN
1 S V U College of Pharmaceutical Sciences, S V University, Tirupati, IN
Source
Research Journal of Topical and Cosmetic Sciences, Vol 8, No 2 (2017), Pagination: 64-71Abstract
Microspheres are categorized under the vesicular drug delivery system, encapsulated by proteins or synthetic polymers which are biodegradable in nature and ideally having a particle size less than 200 μm. The internal structure of the microspheres can vary as a function of the microencapsulation process employed. The encapsulation is carried out by various preparation methods. Microspheres are multiparticulate drug delivery systems which are prepared to obtain prolonged or controlled drug delivery to improve bioavailability, stability and to target the drug to specific site at a predetermined rate. Drugs can be targeted to specific sites in the body using microspheres. The rate of drug release from the microspheres dictates their therapeutic action. Release is governed by the molecular structure of the drug and the polymer, the resistance of the polymer to degradation, and the surface area along with the porosity of the microspheres. This article aims to provide a comprehensive review of advantages, methods of preparation, mechanism, routes of administration, different types of microspheres based on natural and synthetic biodegradable polymers and application of biodegradable polymeric microspheres.Keywords
Microspheres, Microencapsulation, Polymers, Controlled Drug Delivery, Biodegradable.References
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- Development of Medicated Topical Patches in Transdermal Drug Delivery System
Abstract Views :163 |
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Authors
Affiliations
1 SVU College of Pharmaceutical Scieincs, SV Univeristy, Tirupati, IN
1 SVU College of Pharmaceutical Scieincs, SV Univeristy, Tirupati, IN
Source
Research Journal of Pharmacy and Technology, Vol 11, No 1 (2018), Pagination: 397-404Abstract
Transdermal drug delivery system is topically administered medicaments in the form of patches that deliver drugs for systemic effects at a predetermined and controlled rate. These devices allow for pharmaceuticals to be delivered across the skin barrier. Skin is a protective layer of the body, which acts as a barrier against physical, chemical and microbiological invasions. It also regulate the body temperature and blood pressure. The human skin is a readily accessible surface for drug delivery. In addition, Transdermal systems are non-invasive and can be self administered. Transdermal patch is the formulation which is expected to increase the solubility and bioavailability by penetrating poorly water soluble compounds through skin, and it is also possible for this formulation to decrease over-dosing and to avoid hepatic first pass metabolism. Transdermal delivery also has advantages over hypodermic injections, which are painful, generate dangerous medical waste and pose the risk of disease transmission by needle re-use. It has a variety of advantages compared with the oral route. This article mainly describes about composition of patch, types of patches and also explains detailed about evaluation of patches.Keywords
Transdermal Patch, Hypodermic Injection, Polymers.References
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